Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 7/20 | 0.40 |
| ▸ | ABL1 | P00519 | 5/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | BMX | P51813 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27218020 | 1.00 | KDR (0.42) | KDRFGFR1SRCABL1FGFR4 | |
| SCHEMBL27218031 | 0.95 | KDR (0.46) | KDRFGFR1SRCABL1FGFR4 | |
| SCHEMBL30813532 | 0.95 | KDR (0.46) | KDRFGFR1SRCABL1FGFR4 | |
| SCHEMBL30813514 | 0.93 | KDR (0.44) | KDRFGFR1SRCABL1FGFR4 | |
| SCHEMBL27217738 | 0.93 | KDR (0.44) | KDRFGFR1SRCABL1FGFR4 | |
| SCHEMBL30813463 | 0.88 | KDR (0.49) | KDRFGFR1SRCABL1FGFR4 | |
| SCHEMBL27217964 | 0.88 | KDR (0.49) | KDRFGFR1SRCABL1FGFR4 | |
| SCHEMBL27217629 | 0.87 | SRC (0.44) | KDRFGFR1SRCABL1FGFR4 | |
| SCHEMBL30813429 | 0.86 | KDR (0.46) | KDRFGFR1SRCABL1FGFR4 | |
| SCHEMBL27217943 | 0.86 | KDR (0.46) | KDRFGFR1SRCABL1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059200-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2024-03-21 | — | — | WO | disclosed |