SCHEMBL30815569

SCHEMBL30815569

CC(=O)Nc1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(CCl)cc4)c3n2)c1

nearest known ligand 0.88

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 20/20 0.88
AKT2 P31751 15/20 0.88
AKT3 Q9Y243 15/20 0.88
CYP2C9 P11712 5/20 0.88
CYP2C8 P10632 3/20 0.73
CYP2C19 P33261 1/20 0.73
CYP2D6 P10635 2/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27227203 1.00 AKT1 (0.88) AKT1AKT2AKT3CYP2C9CYP2C8
SCHEMBL30574963 0.94 AKT1 (1.00) AKT1AKT2AKT3CYP2C9CYP2C8
SCHEMBL27226703 0.94 AKT1 (0.91) AKT1AKT2AKT3CYP2C9CYP2C8
SCHEMBL2176743 0.94 AKT1 (1.00) AKT1AKT2AKT3CYP2C9CYP2C8
SCHEMBL30815384 0.94 AKT1 (0.91) AKT1AKT2AKT3CYP2C9CYP2C8
SCHEMBL30802341 0.91 AKT1 (0.88) AKT1AKT2AKT3CYP2C9CYP2C8
SCHEMBL2190097 0.91 AKT1 (0.94) AKT1AKT2AKT3CYP2C9CYP2C8
SCHEMBL2174059 0.90 AKT1 (0.87) AKT1AKT2AKT3CYP2C9CYP2C8
SCHEMBL2174671 0.89 AKT1 (1.00) AKT1AKT2AKT3CYP2C9CYP2C8
SCHEMBL2174099 0.89 AKT1 (0.82) AKT1AKT2AKT3CYP2C9CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4594318-A1 AKT1 MODULATORS Alterome Therapeutics, Inc. (US) 2025-08-06 EP disclosed
WO-2024073371-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. (US) 2024-04-04 WO disclosed