Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.50 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.50 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.50 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.49 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20798067 | 0.84 | PDCD1 (0.53) | MTORPIK3CACHEK1ATRPDCD1 | |
| SCHEMBL20651554 | 0.84 | PDCD1 (0.53) | MTORPIK3CACHEK1ATRPDCD1 | |
| SCHEMBL20651590 | 0.83 | ATR (0.69) | MTORPIK3CAPIK3R1CHEK1ATR | |
| SCHEMBL20651543 | 0.83 | ATR (0.69) | PIK3CACHEK1ATRPDCD1ATRIP | |
| SCHEMBL20651740 | 0.83 | ATR (0.69) | PIK3CACHEK1ATRPDCD1ATRIP | |
| SCHEMBL15805547 | 0.82 | MTOR (0.52) | MTORPIK3CAPIK3CDCHEK1ATR | |
| SCHEMBL20692991 | 0.82 | MTOR (0.52) | MTORPIK3CAPIK3CDCHEK1ATR | |
| SCHEMBL15805551 | 0.82 | MTOR (0.52) | MTORPIK3CAPIK3CDCHEK1ATR | |
| SCHEMBL15805506 | 0.82 | MTOR (0.52) | MTORPIK3CAPIK3CDCHEK1ATR | |
| SCHEMBL15805552 | 0.82 | MTOR (0.52) | MTORPIK3CAPIK3CDCHEK1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100227858-A1 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2010-09-09 | — | — | US | disclosed |
| US-20100227858-A1 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2010-09-09 | — | — | US | disclosed |
| US-20100227858-A1 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2010-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227858-A1 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | MTOR, PIK3CA, PIK3CD | MTOR 1/4885PIK3CA 2/4885PIK3R1 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.