Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 19/20 | 0.69 |
| ▸ | SMARCA2 | P51531 | 16/20 | 0.69 |
| ▸ | SMARCA4 | P51532 | 16/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 10/20 | 0.69 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.59 |
| ▸ | BRD4 | O60885 | 2/20 | 0.58 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25610653 | 1.00 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL22794566 | 0.94 | PBRM1 (0.64) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL23303252 | 0.88 | PBRM1 (0.66) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL22794056 | 0.88 | PBRM1 (0.58) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL27457073 | 0.87 | PBRM1 (0.67) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL25125457 | 0.87 | PBRM1 (0.67) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL24514321 | 0.86 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL27457303 | 0.86 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL27455951 | 0.86 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL31396245 | 0.85 | PBRM1 (0.67) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024002375-A1 | COMPOUND FUNCTIONING AS SMARCA2/4 INHIBITOR AND USE THEREOF | 甘李药业股份有限公司 | 2024-01-04 | — | — | WO | disclosed |