Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12296742 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ACYP2C19PARP1 | |
| SCHEMBL4130473 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ACYP2C19PARP1 | |
| SCHEMBL5241453 | 0.85 | HTT (0.58) | USP30SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL3443750 | 0.84 | PARP1 (0.62) | SMN1; SMN2NPC1RAB9ACYP2C19PARP1 | |
| SCHEMBL13106468 | 0.84 | PARP1 (0.62) | SMN1; SMN2NPC1RAB9ACYP2C19PARP1 | |
| SCHEMBL3443753 | 0.84 | PARP1 (0.62) | SMN1; SMN2NPC1RAB9ACYP2C19PARP1 | |
| SCHEMBL204145 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2NPC1RAB9ACYP2C19PARP1 | |
| SCHEMBL3277860 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2NPC1RAB9ACYP2C19PARP1 | |
| SCHEMBL1933206 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2NPC1RAB9ACYP2C19PARP1 | |
| SCHEMBL4004604 | 0.83 | HTT (0.58) | SMN1; SMN2NPC1RAB9ACYP2C19PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117751114-A | Small molecule modulators of glucocerebrosidase activity and uses thereof | 凡况生化公司 | 2024-03-22 | — | — | CN | disclosed |