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SCHEMBL30824848

SCHEMBL30824848

Cc1ccc(S(=O)(=O)n2ccc3c(-c4cc(C5CCS(=O)(=O)CC5)ccc4Oc4ccc(CCC5CCN(C(=O)OC(C)(C)C)CC5)cc4)cn(C)c(=O)c32)cc1

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 8/20 0.46
▸ CSF1R P07333 2/20 0.36
▸ KDR P35968 1/20 0.36
▸ GPR119 Q8TDV5 6/20 0.35
▸ LMNA P02545 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ HTR6 P50406 1/20 0.35
▸ STAT3 P40763 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30824887 0.92 BRD4 (0.47) BRD4CSF1RKDRGPR119LMNA
SCHEMBL30824837 0.92 BRD4 (0.46) BRD4CSF1RKDRGPR119LMNA
SCHEMBL30824785 0.89 BRD4 (0.52) BRD4GPR119
SCHEMBL30824864 0.89 BRD4 (0.49) BRD4CSF1RKDRGPR119LMNA
SCHEMBL30824873 0.89 BRD4 (0.49) BRD4CSF1RKDRGPR119LMNA
SCHEMBL30824779 0.88 BRD4 (0.51) BRD4CSF1RKDRGPR119LMNA
SCHEMBL30824809 0.88 BRD4 (0.48) BRD4GPR119LMNATP53HTR6
SCHEMBL30824812 0.88 BRD4 (0.48) BRD4GPR119LMNATP53HTR6
SCHEMBL30824921 0.87 BRD4 (0.48) BRD4CSF1RKDRGPR119LMNA
SCHEMBL30824830 0.82 BRD4 (0.53) BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024054955-A1 HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE HALDA THERAPEUTICS OPCO, INC. (US) 2024-03-14 — — WO disclosed
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