Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21115066 | 1.00 | PTPN11 (0.49) | PTPN11EGFRKCNH2 | |
| SCHEMBL19785569 | 1.00 | PTPN11 (0.49) | PTPN11EGFRKCNH2 | |
| SCHEMBL30295813 | 1.00 | PTPN11 (0.49) | PTPN11EGFRKCNH2 | |
| SCHEMBL23186806 | 0.92 | PTPN11 (0.53) | PTPN11EGFRKCNH2 | |
| SCHEMBL21154315 | 0.92 | PTPN11 (0.44) | PTPN11EGFRKCNH2 | |
| SCHEMBL25514625 | 0.91 | PTPN11 (0.47) | PTPN11EGFRKCNH2 | |
| SCHEMBL21154404 | 0.89 | PTPN11 (0.56) | PTPN11EGFRKCNH2 | |
| SCHEMBL21154415 | 0.89 | PTPN11 (0.58) | PTPN11EGFRKCNH2 | |
| SCHEMBL23186818 | 0.85 | PTPN11 (0.60) | PTPN11EGFRKCNH2 | |
| SCHEMBL21154168 | 0.84 | PTPN11 (0.52) | PTPN11EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4302834-A2 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2024-01-10 | — | — | EP | disclosed |