SCHEMBL30829342

SCHEMBL30829342

CC(C)c1cc(C(=O)N2Cc3ccc(CN4CC(CN5CCNCC5)C4)cc3C2)c(O)cc1O

nearest known ligand 0.68

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 19/20 0.68
HSP90AB1 P08238 10/20 0.68
HSP90B1 P14625 1/20 0.68
HDAC8 Q9BY41 8/20 0.49
HDAC3 O15379 8/20 0.49
HDAC6 Q9UBN7 8/20 0.49
HDAC1 Q13547 7/20 0.49
HDAC4 P56524 4/20 0.46
HDAC7 Q8WUI4 4/20 0.46
HDAC2 Q92769 4/20 0.46
HDAC10 Q969S8 4/20 0.46
HDAC11 Q96DB2 4/20 0.46
HDAC9 Q9UKV0 4/20 0.46
HDAC5 Q9UQL6 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21097007 0.91 HSP90AA1 (0.81) HSP90AA1HSP90AB1HSP90B1HDAC8HDAC3
Hydrochloric Acid SCHEMBL23673784 0.90 HSP90AA1 (0.80) HSP90AA1HSP90AB1HSP90B1HDAC8HDAC3
Hydrochloric Acid SCHEMBL29974145 0.90 HSP90AA1 (0.80) HSP90AA1HSP90AB1HSP90B1HDAC8HDAC3
SCHEMBL30368762 0.90 HSP90AA1 (0.74) HSP90AA1HSP90AB1HSP90B1HDAC8HDAC3
SCHEMBL25317452 0.90 HSP90AA1 (0.74) HSP90AA1HSP90AB1HSP90B1HDAC8HDAC3
SCHEMBL24321234 0.86 HSP90AA1 (0.60) HSP90AA1HSP90AB1HSP90B1HDAC8HDAC3
SCHEMBL30829341 0.85 HSP90AA1 (0.72) HSP90AA1HSP90AB1HSP90B1HDAC8HDAC3
SCHEMBL30368721 0.83 HSP90AA1 (0.71) HSP90AA1HSP90AB1HSP90B1HDAC8HDAC3
SCHEMBL384367 0.81 HSP90AA1 (0.85) HSP90AA1HSP90AB1HSP90B1HDAC8HDAC3
Onalespib SCHEMBL29351356 0.81 HSP90AA1 (1.00) HSP90AA1HSP90AB1HSP90B1HDAC8HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024034591-A1 HETEROCYCLIC COMPOUND FOR INHIBITING AND/OR INDUCING DEGRADATION OF KRAS PROTEIN アステラス製薬株式会社 2024-02-15 WO disclosed