Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 16/20 | 0.48 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.48 |
| ▸ | BRD1 | O95696 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.48 |
| ▸ | BPTF | Q12830 | 1/20 | 0.48 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.48 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.48 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.48 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.36 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.33 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30830585 | 0.95 | KAT2B (0.48) | KAT2BBRD9BRD1ACHEBRPF1 | |
| SCHEMBL30830696 | 0.93 | KAT2B (0.48) | KAT2BBRD9BRD1ACHEBRPF1 | |
| SCHEMBL30831057 | 0.92 | KAT2B (0.53) | KAT2BBRD9BRD1ACHEBRPF1 | |
| SCHEMBL30830886 | 0.90 | KAT2B (0.53) | KAT2BBRD9BRD1ACHEBRPF1 | |
| SCHEMBL30830554 | 0.89 | KAT2B (0.49) | KAT2BBRD9BRD1ACHEBRPF1 | |
| SCHEMBL30830638 | 0.88 | KAT2B (0.48) | KAT2BBRD9BRD1ACHEBRPF1 | |
| SCHEMBL30830690 | 0.87 | KAT2B (0.47) | KAT2BBRD9BRD1ACHEBRPF1 | |
| SCHEMBL30830829 | 0.86 | KAT2B (0.54) | KAT2BBRD9BRD1ACHEBRPF1 | |
| SCHEMBL30830583 | 0.86 | KAT2B (0.57) | KAT2BBRD9BRD1ACHEBRPF1 | |
| SCHEMBL30830677 | 0.86 | KAT2B (0.44) | KAT2BBRD9BRD1ACHEBRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |