Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 10/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 10/20 | 0.51 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | TNKS | O95271 | 2/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30830796 | 0.85 | DDB1 (0.53) | DDB1CRBNGPR119 | |
| SCHEMBL26641322 | 0.85 | DDB1 (0.51) | DDB1CRBNPARP1TNKSTNKS2 | |
| SCHEMBL27423755 | 0.82 | DDB1 (0.47) | DDB1CRBNPARP1TNKSTNKS2 | |
| SCHEMBL30830587 | 0.82 | MEN1 (0.44) | DDB1CRBNCYP2D6TSHRALDH1A1 | |
| SCHEMBL30732227 | 0.81 | DDB1 (0.66) | DDB1CRBNPARP1TNKSTNKS2 | |
| SCHEMBL26925256 | 0.81 | DDB1 (0.66) | DDB1CRBNPARP1TNKSTNKS2 | |
| SCHEMBL30830900 | 0.80 | DDB1 (0.51) | DDB1CRBNPARP1TNKSTNKS2 | |
| SCHEMBL24319591 | 0.79 | DDB1 (0.58) | DDB1CRBNGPR119 | |
| SCHEMBL27162583 | 0.79 | DDB1 (0.58) | DDB1CRBNGPR119ALDH1A1 | |
| SCHEMBL31727584 | 0.79 | DDB1 (0.52) | DDB1CRBNPARP1TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |