Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.65 |
| ▸ | DDB1 | Q16531 | 14/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26641404 | 0.87 | CRBN (0.63) | CRBNDDB1POLBLMNAMAPT | |
| SCHEMBL31382035 | 0.87 | CRBN (0.63) | CRBNDDB1POLBLMNAMAPT | |
| SCHEMBL25501871 | 0.86 | CRBN (0.65) | CRBNDDB1POLBLMNAMAPT | |
| SCHEMBL24379374 | 0.83 | CRBN (0.62) | CRBNDDB1POLBLMNAMAPT | |
| SCHEMBL31382382 | 0.81 | CRBN (0.59) | CRBNDDB1POLBLMNAMAPT | |
| SCHEMBL26641366 | 0.80 | CRBN (0.66) | CRBNDDB1POLBCYP19A1 | |
| SCHEMBL25198463 | 0.80 | CRBN (0.58) | CRBNDDB1POLBLMNAMAPT | |
| SCHEMBL31382394 | 0.80 | CRBN (0.58) | CRBNDDB1POLBLMNAMAPT | |
| SCHEMBL25198462 | 0.80 | CRBN (0.58) | CRBNDDB1POLBLMNAMAPT | |
| SCHEMBL27022762 | 0.79 | CRBN (1.00) | CRBNDDB1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |