Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 4/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27287711 | 0.79 | EPAS1 (0.37) | SLC22A12PRKCQ | |
| SCHEMBL30687262 | 0.71 | TNF (0.44) | BRD4TRPA1IMPDH2IMPDH1AHR | |
| SCHEMBL25871527 | 0.69 | CHEK1 (0.43) | SLC22A12IKBKBCHUKIMPDH2IMPDH1 | |
| SCHEMBL31357932 | 0.68 | AHR (0.47) | SLC22A12IKBKBCHUKIMPDH2IMPDH1 | |
| SCHEMBL1420429 | 0.68 | AHR (0.47) | SLC22A12IKBKBCHUKIMPDH2IMPDH1 | |
| SCHEMBL29361477 | 0.67 | AHR (0.50) | BRD4TRPA1IMPDH2IMPDH1PRKCQ | |
| SCHEMBL1420318 | 0.67 | AHR (0.50) | BRD4TRPA1IMPDH2IMPDH1PRKCQ | |
| SCHEMBL12100931 | 0.66 | POLB (0.54) | ERBB2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29363603 | 0.66 | AHR (0.48) | BRD4TRPA1IMPDH2IMPDH1PRKCQ | |
| Hydrochloric Acid SCHEMBL27757229 | 0.66 | AHR (0.48) | BRD4TRPA1IMPDH2IMPDH1PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4583972-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | Sionna Therapeutics Inc. (US) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024054840-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | SIONNA THERAPEUTICS (US) | 2024-03-14 | — | — | WO | disclosed |