SCHEMBL30844976

SCHEMBL30844976

CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCN(CC(=O)NC(C)C)CC3)nc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
UGT8 Q16880 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21814139 1.00 UGT8 (1.00) UGT8
SCHEMBL21813999 0.97 UGT8 (0.95) UGT8
SCHEMBL21813358 0.94 UGT8 (0.89) UGT8
SCHEMBL21813431 0.91 UGT8 (0.85) UGT8
SCHEMBL30845101 0.91 UGT8 (0.85) UGT8
SCHEMBL21813715 0.91 UGT8 (0.85) UGT8
SCHEMBL30844987 0.90 UGT8 (0.82) UGT8
SCHEMBL21814063 0.90 UGT8 (0.82) UGT8
SCHEMBL21814173 0.90 UGT8 (1.00) UGT8
SCHEMBL21813609 0.90 UGT8 (0.84) UGT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113423711-B Thieno [3,2-B ] pyridine derivatives as UDP glycosyltransferase inhibitors and methods of use thereof 建新公司 2024-03-15 CN claimed
CN-113423711-B Thieno [3,2-B ] pyridine derivatives as UDP glycosyltransferase inhibitors and methods of use thereof 建新公司 2024-03-15 CN disclosed