Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 4/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21530453 | 1.00 | MAP3K5 (0.51) | MAP3K5PIK3CDPIK3CBPIK3CGTP53 | |
| SCHEMBL21530435 | 0.82 | MAP3K5 (0.50) | MAP3K5LMNAPOLBSMN1; SMN2NPC1 | |
| SCHEMBL30845493 | 0.82 | MAP3K5 (0.50) | MAP3K5LMNAPOLBSMN1; SMN2NPC1 | |
| SCHEMBL23365573 | 0.80 | MAP3K5 (0.39) | MAP3K5PIK3CDPIK3CBPIK3CGLMNA | |
| SCHEMBL21530442 | 0.76 | MAP3K5 (0.43) | MAP3K5PIK3CDPIK3CBPIK3CGTP53 | |
| SCHEMBL30845495 | 0.76 | MAP3K5 (0.43) | MAP3K5PIK3CDPIK3CBPIK3CGTP53 | |
| SCHEMBL25409472 | 0.70 | PSMB8 (0.44) | MAPTSLC6A3LMNAPOLBSMN1; SMN2 | |
| SCHEMBL24296676 | 0.70 | MAP3K5 (0.45) | MAP3K5PIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL18825226 | 0.69 | MAPK1 (0.53) | MAPTMAPK1LMNALCK | |
| SCHEMBL24724195 | 0.69 | MAPK1 (0.46) | MAPK1LMNAPOLBLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112312905-B | Tetrazole-containing inhibitors of apoptosis signal-regulating kinase 1 and methods of use thereof | 英安塔制药有限公司 | 2024-03-15 | — | — | CN | disclosed |