Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22632577 | 0.87 | MEN1 (0.51) | MEN1KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL24029215 | 0.81 | AKR1B1 (0.43) | MEN1KMT2AALDH1A1GAAAKR1B1 | |
| SCHEMBL23835847 | 0.81 | AKR1B1 (0.43) | MEN1KMT2AALDH1A1GAAAKR1B1 | |
| SCHEMBL23836087 | 0.80 | AKR1B1 (0.44) | CMA1AHRHTR6AKR1B1PKM | |
| SCHEMBL24019924 | 0.80 | KMT2A (0.40) | MEN1KMT2AHTR6AKR1B1TGM2 | |
| SCHEMBL23835757 | 0.80 | KMT2A (0.40) | MEN1KMT2AHTR6AKR1B1TGM2 | |
| SCHEMBL23835849 | 0.80 | AKR1B1 (0.44) | CMA1AHRHTR6AKR1B1PKM | |
| SCHEMBL1223198 | 0.79 | PDK2 (0.55) | MEN1KMT2AALDH1A1CMA1AHR | |
| SCHEMBL29519108 | 0.79 | PDK2 (0.55) | MEN1KMT2AALDH1A1CMA1AHR | |
| SCHEMBL15210589 | 0.79 | MEN1 (0.56) | MEN1KMT2AALDH1A1CMA1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024064316-A1 | COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 INHIBITORS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-03-28 | — | — | WO | disclosed |