SCHEMBL30847710

SCHEMBL30847710

[2H]C([2H])([2H])N(C(=O)Oc1c(N2CCN(CC3CO3)C2=O)cc(C(F)(F)F)cc1C(F)(F)F)c1ccc(F)c(Cl)c1F

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
POLQ O75417 2/20 0.38
P2RX7 Q99572 3/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30847661 0.95 POLQ (0.41) POLQP2RX7
SCHEMBL30847711 0.85 POLQ (0.41) POLQP2RX7
SCHEMBL30847706 0.85 POLQ (0.41) POLQP2RX7
SCHEMBL30847705 0.85 POLQ (0.41) POLQP2RX7
SCHEMBL30847651 0.85 POLQ (0.36) POLQ
SCHEMBL30847648 0.85 POLQ (0.33) POLQ
SCHEMBL30847743 0.84 POLQ (0.38) POLQP2RX7
SCHEMBL30847849 0.84 POLQ (0.34) POLQP2RX7
SCHEMBL30847683 0.81 POLQ (0.38) POLQP2RX7
SCHEMBL30847731 0.81 POLQ (0.38) POLQP2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4598901-A1 PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF Thomas Jefferson University (US) 2025-08-13 EP disclosed
WO-2024076964-A1 PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF THOMAS JEFFERSON UNIVERSITY (US) 2024-04-11 WO disclosed