Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.50 |
| ▸ | CCNC | P24863 | 4/20 | 0.36 |
| ▸ | CDK8 | P49336 | 4/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | BCL6 | P41182 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24826464 | 1.00 | EGFR (0.50) | EGFRCCNCCDK8NOTUMSOS1 | |
| SCHEMBL24824609 | 0.88 | EGFR (0.40) | EGFRNOTUMPOLBTDP1L3MBTL1 | |
| SCHEMBL30848800 | 0.88 | EGFR (0.40) | EGFRNOTUMPOLBTDP1L3MBTL1 | |
| SCHEMBL30848793 | 0.85 | EGFR (0.39) | EGFRPOLBBCL6 | |
| SCHEMBL24827270 | 0.85 | EGFR (0.39) | EGFRPOLBBCL6 | |
| SCHEMBL24826754 | 0.85 | EGFR (0.40) | EGFR | |
| SCHEMBL30164940 | 0.85 | EGFR (0.40) | EGFR | |
| SCHEMBL24825129 | 0.85 | EGFR (0.51) | EGFRNOTUM | |
| SCHEMBL30848806 | 0.85 | EGFR (0.51) | EGFRNOTUM | |
| SCHEMBL24826745 | 0.83 | EGFR (0.46) | EGFRSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858872-A | Heterocyclic EGFR inhibitors for the treatment of cancer | 缆图药品公司 | 2024-04-09 | — | — | CN | disclosed |