Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | STK4 | Q13043 | 1/20 | 0.46 |
| ▸ | STK3 | Q13188 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16968469 | 0.85 | CDK8 (0.59) | CDK8STK4STK3JAK2JAK1 | |
| SCHEMBL857022 | 0.76 | CDK8 (0.58) | CDK8STK3PIM1RPS6KA5GSK3B | |
| SCHEMBL30124898 | 0.71 | STK4 (0.61) | CDK8STK4STK3JAK2JAK1 | |
| SCHEMBL12764139 | 0.69 | CDK8 (0.85) | CDK8NTRK1PIK3CA | |
| SCHEMBL27094478 | 0.69 | CDK8 (0.53) | CDK8STK4STK3CHEK1TDO2 | |
| SCHEMBL8316949 | 0.67 | CDK8 (0.67) | CDK8NTRK1PIK3CA | |
| SCHEMBL8256242 | 0.65 | CDK8 (0.72) | CDK8NTRK1PIK3CA | |
| SCHEMBL13651106 | 0.65 | CDK8 (0.76) | CDK8STK3CHEK1PIM1PIM3 | |
| SCHEMBL223072 | 0.65 | HSD17B10 (0.51) | CDK8TDO2PIM1RAB9AATM | |
| SCHEMBL25198274 | 0.65 | CDK8 (0.49) | CDK8STK4STK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117460736-A | Nucleoside derivatives having multi-target phosphorylase inhibitory activity and pharmaceutical compositions for preventing and treating cancer comprising the same | 未来制药有限公司 | 2024-01-26 | — | — | CN | disclosed |