SCHEMBL30850146

SCHEMBL30850146

CC(c1cccnc1NC(=O)OC(C)(C)C)N1C[C@H](C)Oc2nc(Cl)c(F)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc1c23

nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
KRAS P01116 16/20 0.41
MAPK3 P27361 4/20 0.40
MAPK1 P28482 4/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30850149 1.00 KRAS (0.41) KRASMAPK3MAPK1
SCHEMBL30978020 0.92 MAPK3 (0.42) KRASMAPK3MAPK1
SCHEMBL29327550 0.92 MAPK3 (0.42) KRASMAPK3MAPK1
SCHEMBL29321747 0.92 MAPK3 (0.42) KRASMAPK3MAPK1
SCHEMBL30850158 0.92 MAPK3 (0.42) KRASMAPK3MAPK1
SCHEMBL29330252 0.83 KRAS (0.41) KRAS
SCHEMBL30978050 0.81 KRAS (0.51) KRASMAPK3MAPK1
SCHEMBL30850157 0.81
SCHEMBL29322398 0.81 KRAS (0.33) KRASMAPK3MAPK1
SCHEMBL29321777 0.80 MAPK3 (0.43) KRASMAPK3MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4605400-A1 NOVEL TRIHETEROCYCLIC COMPOUNDS Idience Co., Ltd. (KR) 2025-08-27 EP disclosed
WO-2024085661-A1 NOVEL TRIHETEROCYCLIC COMPOUNDS ILDONG PHARMACEUTICAL CO., LTD. (KR) 2024-04-25 WO disclosed