SCHEMBL30850176

SCHEMBL30850176

COCOc1cc(-c2nc3c4c(nc(OC[C@@]56CCCN5C[C@H](F)C6)nc4c2F)N(C(C)c2ccccc2NC(=O)OC(C)(C)C)CCO3)c2c(C#C[Si](C(C)C)(C(C)C)C(C)C)c(F)ccc2c1

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAPK3 P27361 8/20 0.43
MAPK1 P28482 8/20 0.43
KRAS P01116 13/20 0.41
RAF1 P04049 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30978049 0.94 MAPK3 (0.43) MAPK3MAPK1KRASRAF1
SCHEMBL29321761 0.94 MAPK3 (0.43) MAPK3MAPK1KRASRAF1
SCHEMBL30850173 0.94 MAPK3 (0.50) MAPK3MAPK1KRASRAF1
SCHEMBL29321751 0.92 MAPK3 (0.40) MAPK3MAPK1KRASRAF1
SCHEMBL31527172 0.91 MAPK3 (0.42) MAPK3MAPK1KRASRAF1
SCHEMBL30978065 0.88 MAPK3 (0.49) MAPK3MAPK1KRASRAF1
SCHEMBL29321765 0.88 MAPK3 (0.49) MAPK3MAPK1KRASRAF1
SCHEMBL29321757 0.86 MAPK3 (0.47) MAPK3MAPK1KRASRAF1
SCHEMBL30850184 0.85
SCHEMBL30850182 0.85

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4605400-A1 NOVEL TRIHETEROCYCLIC COMPOUNDS Idience Co., Ltd. (KR) 2025-08-27 EP disclosed
WO-2024085661-A1 NOVEL TRIHETEROCYCLIC COMPOUNDS ILDONG PHARMACEUTICAL CO., LTD. (KR) 2024-04-25 WO disclosed