Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.83 |
| ▸ | DDB1 | Q16531 | 12/20 | 0.83 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.56 |
| ▸ | IL1B | P01584 | 1/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.56 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | CCNK | O75909 | 1/20 | 0.53 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30850416 | 0.99 | CRBN (0.82) | CRBNDDB1MAP1LC3BSTAT3TNF | |
| SCHEMBL30850474 | 0.99 | CRBN (0.82) | CRBNDDB1MAP1LC3BSTAT3TNF | |
| SCHEMBL24621043 | 0.96 | CRBN (0.83) | CRBNDDB1MAP1LC3BSTAT3TNF | |
| SCHEMBL21062689 | 0.91 | CRBN (0.75) | CRBNDDB1MAP1LC3BSTAT3TNF | |
| SCHEMBL22500886 | 0.91 | CRBN (0.75) | CRBNDDB1MAP1LC3BSTAT3TNF | |
| SCHEMBL20975160 | 0.91 | CRBN (0.75) | CRBNDDB1MAP1LC3BSTAT3TNF | |
| SCHEMBL29360230 | 0.91 | CRBN (1.00) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL14085581 | 0.91 | CRBN (1.00) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL24621039 | 0.91 | CRBN (0.77) | CRBNDDB1MAP1LC3BSTAT3TNF | |
| SCHEMBL21224312 | 0.89 | DDB1 (0.81) | CRBNDDB1MAP1LC3BSTAT3TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024102970-A1 | COMPOUNDS FOR MODULATING SYK ACTIVITY AND E3 UBIQUITIN LIGASE ACTIVITY | Kronos Bio, Inc. (US) | 2024-05-16 | — | — | WO | disclosed |