Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 8/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.47 |
| ▸ | CDK1 | P06493 | 6/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.47 |
| ▸ | CDK9 | P50750 | 6/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.47 |
| ▸ | TTK | P33981 | 4/20 | 0.44 |
| ▸ | CDK4 | P11802 | 3/20 | 0.42 |
| ▸ | CCND1 | P24385 | 3/20 | 0.42 |
| ▸ | CCND3 | P30281 | 3/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30851339 | 0.90 | CCNE1 (0.53) | JAK2JAK1JAK3CDK2CCNE1 | |
| SCHEMBL30851385 | 0.90 | CDK1 (0.47) | JAK2JAK1JAK3CDK2CCNE1 | |
| SCHEMBL30851347 | 0.89 | CCNE1 (0.49) | JAK2JAK1JAK3CDK2CCNE1 | |
| SCHEMBL30851390 | 0.85 | CDK2 (0.49) | JAK2JAK1JAK3CDK2CCNE1 | |
| SCHEMBL30851366 | 0.84 | JAK1 (0.44) | JAK2JAK1JAK3CDK2CCNE1 | |
| SCHEMBL31121915 | 0.84 | TTK (0.55) | CDK2CCNE1CDK1CCNB1CDK9 | |
| SCHEMBL30851398 | 0.83 | CDK1 (0.48) | JAK2JAK1JAK3CDK2CCNE1 | |
| SCHEMBL30851361 | 0.83 | JAK1 (0.44) | JAK2JAK1JAK3CDK2CCNE1 | |
| SCHEMBL30851319 | 0.81 | CDK1 (0.54) | JAK2JAK1JAK3CDK2CCNE1 | |
| SCHEMBL31121909 | 0.81 | CDK2 (0.69) | JAK2JAK1JAK3CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117813300-A | Substituted pyrimidinyl-pyrazoles as CDK2 inhibitors | 缆图药品公司 | 2024-04-02 | — | — | CN | disclosed |