Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30618089 | 1.00 | EGFR (0.55) | EGFRPIK3CDPIK3CACYP11B1CYP11B2 | |
| SCHEMBL3393275 | 1.00 | EGFR (0.55) | EGFRPIK3CDPIK3CACYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL30376208 | 0.98 | EGFR (0.53) | EGFRPIK3CDPIK3CACYP11B1CYP11B2 | |
| SCHEMBL27788810 | 0.98 | EGFR (0.53) | EGFRPIK3CDPIK3CACYP11B1CYP11B2 | |
| Formic Acid SCHEMBL30375687 | 0.91 | EGFR (0.46) | EGFRPIK3CDPIK3CACYP11B1CYP11B2 | |
| SCHEMBL27557205 | 0.85 | EGFR (0.55) | EGFRCYP11B1CYP11B2HPGDSCYP17A1 | |
| SCHEMBL30466518 | 0.82 | MAP4K4 (0.39) | EGFRCYP11B1CYP11B2HPGDSCYP17A1 | |
| SCHEMBL2011007 | 0.81 | EGFR (0.55) | EGFRPIK3CDPIK3CAFGFR4TDO2 | |
| SCHEMBL737948 | 0.81 | EGFR (0.55) | EGFRPIK3CDPIK3CAFGFR4TDO2 | |
| SCHEMBL30643233 | 0.79 | MAP4K4 (0.61) | EGFRPIK3CDPIK3CACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117881681-A | Substituted pyrrolo [2,3-d ] pyrimidines, their preparation and their therapeutic use | 赛诺菲 | 2024-04-12 | — | — | CN | disclosed |