Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 1.00 |
| ▸ | JAK3 | P52333 | 6/20 | 1.00 |
| ▸ | JAK2 | O60674 | 3/20 | 1.00 |
| ▸ | BLK | P51451 | 2/20 | 1.00 |
| ▸ | BMX | P51813 | 2/20 | 1.00 |
| ▸ | BTK | Q06187 | 6/20 | 0.80 |
| ▸ | FLT3 | P36888 | 2/20 | 0.80 |
| ▸ | CTSC | P53634 | 2/20 | 0.80 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.80 |
| ▸ | PLK4 | O00444 | 1/20 | 0.80 |
| ▸ | GAK | O14976 | 1/20 | 0.80 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.80 |
| ▸ | ITK | Q08881 | 1/20 | 0.80 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.80 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.80 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.80 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.80 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.80 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.80 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL93510 | 1.00 | EGFR (1.00) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL29351880 | 1.00 | EGFR (1.00) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL10127835 | 0.91 | EGFR (0.84) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL1707115 | 0.91 | EGFR (0.83) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL10127821 | 0.90 | EGFR (0.82) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL22210826 | 0.90 | EGFR (0.84) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL19725766 | 0.90 | EGFR (0.84) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL30672758 | 0.90 | EGFR (0.81) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL16372156 | 0.90 | EGFR (0.81) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL10127920 | 0.89 | EGFR (0.81) | EGFRJAK3JAK2BLKBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4662319-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | Integrate Bioscience LLC (US) | 2025-12-17 | — | — | EP | disclosed |
| WO-2024168301-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | FUNCTION ONCOLOGY, INC. (US) | 2024-08-15 | — | — | WO | disclosed |
| US-20240245634-A1 | PCNA INHIBITORS AND EGFR INHIBITORS FOR CANCER TREATMENT | UNITED STATES GOVERNMENT | 2024-07-25 | — | — | US | disclosed |
| EP-4330224-A1 | PCNA INHIBITORS AND EGFR INHIBITORS FOR CANCER TREATMENT | City of Hope (US) | 2024-03-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240245634-A1 | PCNA INHIBITORS AND EGFR INHIBITORS FOR CANCER TREATMENT | PCNA, MKI67, EGFR | EGFR 3/4885JAK3 922/4885JAK2 741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.