SCHEMBL30855048

SCHEMBL30855048

C=CC(=O)N1[C@H](c2cc(Cl)nc(-c3ccnc(C)n3)c2)COC[C@H]1C(F)F

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KRAS P01116 1/20 0.31
IDH1 O75874 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31008647 0.90 KRAS (0.30) KRAS
SCHEMBL29335948 0.90 KRAS (0.30) KRAS
SCHEMBL29333662 0.90 KRAS (0.30) KRAS
SCHEMBL30855082 0.88 KRAS (0.31) KRAS
SCHEMBL29333572 0.88 KRAS (0.31) KRAS
SCHEMBL29335938 0.86 KRAS (0.31) KRAS
SCHEMBL30855039 0.86 KRAS (0.31) KRAS
SCHEMBL29333658 0.86 KRAS (0.31) KRAS
SCHEMBL29335945 0.82 KRAS (0.35) KRAS
SCHEMBL29333660 0.82 KRAS (0.35) KRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4594308-A1 N-ACRYLOYLMORPHOLINE DERIVATIVES AS KEAP1 MODULATORS AND USES THEREOF Vividion Therapeutics, Inc. (US) 2025-08-06 EP claimed
WO-2024073587-A1 N-ACRYLOYLMORPHOLINE DERIVATIVES AS KEAP1 MODULATORS AND USES THEREOF VIVIDION THERAPEUTICS, INC. (US) 2024-04-04 WO claimed