Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 10/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175120 | 0.84 | POLB (0.46) | MGLLMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL30857630 | 0.84 | POLB (0.46) | MGLLMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL3956681 | 0.84 | GAA (0.53) | MEN1KMT2AUSP2ALDH1A1LMNA | |
| SCHEMBL10224819 | 0.79 | BCL2 (0.50) | USP2ENPP2ALDH1A1LMNABCL2 | |
| SCHEMBL31451040 | 0.78 | BCL2L1 (0.46) | USP2ENPP2ALDH1A1LMNABCL2 | |
| SCHEMBL31450836 | 0.78 | BCL2L1 (0.46) | USP2ENPP2ALDH1A1LMNABCL2 | |
| SCHEMBL553747 | 0.78 | BCL2L1 (0.46) | USP2ENPP2ALDH1A1LMNABCL2 | |
| SCHEMBL554396 | 0.78 | BCL2L1 (0.46) | USP2ENPP2ALDH1A1LMNABCL2 | |
| SCHEMBL553748 | 0.78 | BCL2L1 (0.46) | USP2ENPP2ALDH1A1LMNABCL2 | |
| SCHEMBL19491791 | 0.77 | USP2 (0.44) | NOTUMUSP2ENPP2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024067818-A1 | CHIMERIC COMPOUND USED FOR TARGETED DEGRADATION OF BCL-2 PROTEIN, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 江苏恒瑞医药股份有限公司 | 2024-04-04 | — | — | WO | disclosed |