SCHEMBL30858798

SCHEMBL30858798

Nc1nc2c(cnn2CCN2CCN(c3ccc(OCC[18F])cc3)CC2)c2nc(-c3ccco3)nn12

nearest known ligand 0.88

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 19/20 0.88
ADORA1 P30542 1/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30543453 1.00 ADORA2A (0.88) ADORA2AADORA1
SCHEMBL21832807 0.95 ADORA2A (0.87) ADORA2AADORA1
SCHEMBL8287839 0.94 ADORA2A (1.00) ADORA2AADORA1
SCHEMBL21833625 0.92 ADORA2A (0.86) ADORA2AADORA1
Preladenant SCHEMBL2856554 0.92 ADORA2A (1.00) ADORA2AADORA1
SCHEMBL21833111 0.90 ADORA2A (0.84) ADORA2AADORA1
SCHEMBL8243159 0.90 ADORA2A (0.87) ADORA2AADORA1
SCHEMBL12969346 0.90 ADORA2A (0.86) ADORA2AADORA1
SCHEMBL8243358 0.89 ADORA2A (0.85) ADORA2AADORA1
SCHEMBL14922357 0.88 ADORA2A (0.83) ADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117946123-A Radioactive triazolopyrimidinyl derivative, and preparation method and application thereof 北京脑重大疾病研究院 2024-04-30 CN disclosed