Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 2/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30204424 | 0.75 | KDM4C (0.38) | PDE1CKDM4EPDE1APDE1B | |
| SCHEMBL17338962 | 0.75 | KDM4E (0.38) | PDE1CKDM4ENPC1MAPK1RAB9A | |
| SCHEMBL31647105 | 0.74 | CA1 (0.38) | PDE1CMAPK1PDE1APDE1BAURKA | |
| SCHEMBL16506461 | 0.72 | KDM4E (0.38) | KDM4ENPC1MAPK1RAB9A | |
| SCHEMBL30204357 | 0.71 | JMJD6 (0.39) | KDM4ENPC1MAPK1RAB9A | |
| SCHEMBL31646629 | 0.71 | KDM1A (0.35) | PDE1CKDM4EPDE1APDE1B | |
| SCHEMBL23851626 | 0.70 | PDE1C (0.37) | PDE1CKDM4EPDE1APDE1BAURKA | |
| SCHEMBL20049608 | 0.70 | USP30 (0.42) | KDM4EAURKAJAK2JAK1KDR | |
| SCHEMBL31647022 | 0.68 | MAPT (0.40) | KDM4E | |
| SCHEMBL31646854 | 0.68 | PARG (0.32) | PDE1CPDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858877-A | C-linked inhibitors of ENL/AF9 YEATS | 桥梁药品有限公司 | 2024-04-09 | — | — | CN | disclosed |