Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ccx354. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 known ✓ | P32246 | 20/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ccx354 SCHEMBL1638749 | 1.00 | CCR1 (1.00) | CCR1CYP2C19KCNH2 | |
| Ccx354 SCHEMBL30538013 | 1.00 | CCR1 (1.00) | CCR1CYP2C19KCNH2 | |
| Ccx354 SCHEMBL29364104 | 1.00 | CCR1 (1.00) | CCR1CYP2C19KCNH2 | |
| SCHEMBL1638044 | 0.93 | CCR1 (0.87) | CCR1CYP2C19KCNH2 | |
| SCHEMBL10080244 | 0.91 | CCR1 (0.83) | CCR1CYP2C19KCNH2 | |
| SCHEMBL1638693 | 0.90 | CCR1 (0.82) | CCR1CYP2C19KCNH2 | |
| SCHEMBL1639499 | 0.90 | CCR1 (0.82) | CCR1CYP2C19KCNH2 | |
| SCHEMBL1638600 | 0.90 | CCR1 (0.81) | CCR1CYP2C19KCNH2 | |
| SCHEMBL1637790 | 0.88 | CCR1 (0.79) | CCR1 | |
| SCHEMBL1638041 | 0.88 | CCR1 (0.79) | CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119587697-A | Compositions comprising mCCL6/hCCL15-CCR1 signaling pathway blockers and uses thereof | 南京大学 | 2025-03-11 | — | — | CN | claimed |
| EP-4608403-A1 | MODULATORS AND USES THEREOF | Hadasit Medical Research Services&Development Ltd. (IL) | 2025-09-03 | — | — | EP | disclosed |
| CN-119587697-A | Compositions comprising mCCL6/hCCL15-CCR1 signaling pathway blockers and uses thereof | 南京大学 | 2025-03-11 | — | — | CN | disclosed |
| WO-2024089691-A1 | MODULATORS AND USES THEREOF | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD (IL) | 2024-05-02 | — | — | WO | disclosed |