Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.53 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.53 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.53 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.53 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | PDE8A | O60658 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | PDE8B | O95263 | 1/20 | 0.47 |
| ▸ | PDE6A | P16499 | 1/20 | 0.47 |
| ▸ | PDE6G | P18545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30928050 | 0.83 | PARP1 (0.71) | PARP1GRIN2DGRIN3BGRIA1GRIA2 | |
| SCHEMBL3084498 | 0.78 | PARP1 (1.00) | PARP1GRIN2DGRIN3BGRIA1GRIA2 | |
| SCHEMBL3068560 | 0.77 | PARP1 (0.98) | PARP1GRIN2DGRIN3BGRIA1GRIA2 | |
| SCHEMBL3495517 | 0.76 | GRIA1 (0.61) | PARP1GRIN2DGRIN3BGRIA1GRIA2 | |
| SCHEMBL3068633 | 0.75 | PARP1 (0.81) | PARP1GRIN2DGRIN3BGRIA1GRIA2 | |
| SCHEMBL3494657 | 0.73 | PARP1 (0.57) | PARP1GRIN2DGRIN3BGRIA1GRIA2 | |
| SCHEMBL31377420 | 0.73 | PARP1 (0.57) | PARP1GRIN2DGRIN3BGRIA1GRIA2 | |
| SCHEMBL3072183 | 0.72 | PARP1 (0.60) | PARP1GRIN2DGRIN3BGRIA1GRIA2 | |
| SCHEMBL30273078 | 0.72 | PDE2A (0.69) | PARP1GRIN2DGRIN3BGRIA1GRIA2 | |
| SCHEMBL2818529 | 0.72 | PDE2A (0.69) | PARP1GRIN2DGRIN3BGRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114948-B1 | INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBVIE INC (US) | 2014-06-25 | — | — | EP | disclosed |
| US-7790721-B2 | Pyrroloquinoxalinone inhibitors of poly(ADP-ribose)polymerase | ABBOTT LABORATORIES (US) | 2010-09-07 | — | — | US | disclosed |
| EP-2114948-A2 | INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | Abbott Laboratories (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008082887-A2 | INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2008-07-10 | — | — | WO | disclosed |
| US-20080161292-A1 | INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161292-A1 | INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | PARP1, PARP2, PARP3 | PARP1 1/4885GRIN2D 3490/4885GRIN3B 1637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.