Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 11/20 | 0.46 |
| ▸ | GRM5 | P41594 | 11/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31703338 | 0.86 | GRM1 (0.46) | GRM1GRM5PDK4NAMPTCYP11B2 | |
| SCHEMBL30867744 | 0.78 | GRM1 (0.46) | GRM1GRM5PDK4NAMPTCYP11B2 | |
| SCHEMBL31283151 | 0.77 | GRM1 (0.47) | GRM1GRM5PDK4NAMPTCYP11B2 | |
| SCHEMBL30872359 | 0.74 | MAPT (0.47) | — | |
| SCHEMBL2517844 | 0.72 | GRM1 (0.47) | GRM1GRM5PDK4NAMPTCYP11B2 | |
| SCHEMBL15756310 | 0.72 | GRM1 (0.55) | GRM1GRM5PDK4NAMPTCYP11B2 | |
| SCHEMBL20135287 | 0.70 | GRM1 (0.52) | GRM1GRM5PDK4NAMPTCYP11B2 | |
| SCHEMBL8912847 | 0.70 | NAMPT (0.63) | GRM1GRM5PDK4NAMPTCYP11B2 | |
| SCHEMBL23411394 | 0.70 | GRM1 (0.53) | GRM1GRM5PDK4NAMPTCYP11B2 | |
| SCHEMBL16992156 | 0.70 | GRM1 (0.52) | GRM1GRM5PDK4NAMPTCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598916-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076672-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |