Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 11/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14657365 | 1.00 | MAPK8 (0.49) | MAPK8MAPK9HDAC3HDAC1HDAC2 | |
| SCHEMBL13733963 | 0.82 | MAPK8 (0.51) | MAPK8MAPK9HDAC3HDAC1HDAC2 | |
| SCHEMBL30873244 | 0.77 | MAPK8 (0.46) | MAPK8MAPK9NNMTSYK | |
| SCHEMBL13734724 | 0.77 | MAPK8 (0.46) | MAPK8MAPK9NNMTSYK | |
| SCHEMBL14657149 | 0.76 | MAPK8 (0.51) | MAPK8MAPK9HDAC3HDAC1HDAC2 | |
| SCHEMBL14657418 | 0.74 | MAPK8 (0.61) | MAPK8MAPK9 | |
| SCHEMBL30873301 | 0.74 | MAPK8 (0.61) | MAPK8MAPK9 | |
| SCHEMBL14657416 | 0.74 | MAPK8 (0.61) | MAPK8MAPK9 | |
| SCHEMBL13734392 | 0.72 | MAPK8 (0.64) | MAPK8MAPK9SYK | |
| SCHEMBL13734397 | 0.72 | MAPK8 (0.64) | MAPK8MAPK9SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111471021-B | Substituted diamino carboxamides and diamino carbonitrile pyrimidines, compositions thereof, and methods of treatment therewith | 西格诺药品有限公司 | 2024-04-02 | — | — | CN | disclosed |