Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | S100B | P04271 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24869723 | 1.00 | MEN1 (0.77) | MEN1KMT2AGAASMN1; SMN2BRD4 | |
| SCHEMBL20214033 | 0.91 | MEN1 (0.64) | MEN1KMT2AGAASMN1; SMN2BRD4 | |
| SCHEMBL30883376 | 0.87 | MEN1 (1.00) | MEN1KMT2AGAASMN1; SMN2BRD4 | |
| SCHEMBL11923834 | 0.87 | MEN1 (1.00) | MEN1KMT2AGAASMN1; SMN2BRD4 | |
| SCHEMBL2061017 | 0.85 | MEN1 (0.64) | MEN1KMT2AGAASMN1; SMN2BRD4 | |
| SCHEMBL14993330 | 0.84 | MEN1 (0.54) | MEN1KMT2AGAASMN1; SMN2BRD4 | |
| SCHEMBL29989787 | 0.84 | MEN1 (0.54) | MEN1KMT2AGAASMN1; SMN2BRD4 | |
| Thalifoline SCHEMBL29961712 | 0.82 | MEN1 (0.77) | MEN1KMT2AGAASMN1; SMN2BRD4 | |
| SCHEMBL25946921 | 0.81 | MEN1 (0.75) | MEN1KMT2AGAASMN1; SMN2BRD4 | |
| SCHEMBL16519579 | 0.80 | MEN1 (0.79) | MEN1KMT2AGAASMN1; SMN2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117730083-A | Pyrimidine compounds as MAP4K1 inhibitors | 格兰马克专业公司 | 2024-03-19 | — | — | CN | disclosed |