SCHEMBL30876112

SCHEMBL30876112

Cc1cc(C(F)(F)F)nc(Br)c1N

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.48
HSP90AB1 P08238 1/20 0.48
KDM4E B2RXH2 7/20 0.40
ALDH1A1 P00352 4/20 0.37
HSD17B10 Q99714 2/20 0.35
CA2 P00918 1/20 0.34
CHKA P35790 1/20 0.34
LMNA P02545 1/20 0.34
KMT2A Q03164 1/20 0.34
NT5E P21589 1/20 0.34
CDK8 P49336 1/20 0.34
CDK19 Q9BWU1 1/20 0.34
ADORA2A P29274 2/20 0.33
ADORA1 P30542 2/20 0.33
CYP3A4 P08684 2/20 0.33
TSHR P16473 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
POLB P06746 1/20 0.33
CFTR P13569 1/20 0.33
TP53 P04637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18299317 1.00 HSP90AA1 (0.48) HSP90AA1HSP90AB1KDM4EALDH1A1HSD17B10
SCHEMBL21596956 0.80 HSP90AA1 (0.42) HSP90AA1HSP90AB1KDM4EALDH1A1HSD17B10
SCHEMBL21603492 0.80 HSP90AA1 (0.52) HSP90AA1HSP90AB1KDM4EALDH1A1HSD17B10
SCHEMBL9952772 0.80 HSP90AA1 (0.52) HSP90AA1HSP90AB1KDM4EALDH1A1HSD17B10
SCHEMBL11985870 0.80 HSP90AA1 (0.42) HSP90AA1HSP90AB1KDM4EALDH1A1HSD17B10
SCHEMBL30374282 0.80 HSP90AA1 (0.42) HSP90AA1HSP90AB1KDM4EALDH1A1HSD17B10
SCHEMBL18299534 0.78 HSP90AA1 (0.50) HSP90AA1HSP90AB1KDM4EALDH1A1HSD17B10
SCHEMBL21625478 0.77 HSP90AA1 (0.41) HSP90AA1HSP90AB1KDM4EALDH1A1HSD17B10
SCHEMBL30054247 0.73 HSP90AA1 (0.48) HSP90AA1HSP90AB1KDM4EALDH1A1HSD17B10
SCHEMBL19711936 0.73 HSP90AA1 (0.48) HSP90AA1HSP90AB1KDM4EALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111683950-B AhR modulators 伊迪亚生物科学有限公司 2024-04-16 CN disclosed