Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | ELANE | P08246 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9232274 | 1.00 | KMT2A (0.74) | KMT2AHTTSMN1; SMN2TDP1POLB | |
| SCHEMBL10958586 | 0.98 | POLB (0.76) | KMT2AHTTSMN1; SMN2TDP1POLB | |
| SCHEMBL10781602 | 0.98 | POLB (0.76) | KMT2AHTTSMN1; SMN2TDP1POLB | |
| SCHEMBL10955343 | 0.98 | POLB (0.76) | KMT2AHTTSMN1; SMN2TDP1POLB | |
| SCHEMBL10782887 | 0.98 | POLB (0.76) | KMT2AHTTSMN1; SMN2TDP1POLB | |
| SCHEMBL10949493 | 0.98 | POLB (0.76) | KMT2AHTTSMN1; SMN2TDP1POLB | |
| SCHEMBL10911289 | 0.98 | POLB (0.76) | KMT2AHTTSMN1; SMN2TDP1POLB | |
| SCHEMBL234456 | 0.98 | POLB (0.76) | KMT2AHTTSMN1; SMN2TDP1POLB | |
| SCHEMBL10782854 | 0.98 | POLB (0.76) | KMT2AHTTSMN1; SMN2TDP1POLB | |
| SCHEMBL10955716 | 0.98 | POLB (0.76) | KMT2AHTTSMN1; SMN2TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024088189-A1 | MACROCYCLIC COMPOUND AS CDK9 INHIBITOR AND USE THEREOF | 科辉智药生物科技（无锡）有限公司 | 2024-05-02 | — | — | WO | disclosed |