SCHEMBL30878435

SCHEMBL30878435

C#Cc1cc(=O)n(-c2ccccc2)c2nc(Nc3ccc(N(C)CCCN(C)C)cc3)ncc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 5/20 0.43
CDK4 P11802 3/20 0.43
CCND1 P24385 3/20 0.43
CCND2 P30279 2/20 0.43
CCND3 P30281 2/20 0.43
WEE1 P30291 2/20 0.43
CCNT1 O60563 2/20 0.42
CDK9 P50750 2/20 0.42
TNK2 Q07912 3/20 0.41
FGFR4 P22455 1/20 0.40
FLT3 P36888 1/20 0.40
BLK P51451 1/20 0.40
GSK3B P49841 1/20 0.39
LCK P06239 1/20 0.39
SRC P12931 1/20 0.39
KDR P35968 1/20 0.39
KCNH2 Q12809 1/20 0.39
FGFR1 P11362 1/20 0.39
MAP4K1 Q92918 1/20 0.39
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30878419 0.95 EGFR (0.48) EGFRCDK4CCND1CCND2CCND3
SCHEMBL30879043 0.87 EGFR (0.40) EGFRCDK4CCND1CCND2CCND3
SCHEMBL30878466 0.86 CDK4 (0.53) EGFRCDK4CCND1CCND2CCND3
SCHEMBL30878490 0.84 CDK4 (0.60) EGFRCDK4CCND1CCND2CCND3
SCHEMBL30878297 0.84 EGFR (0.44) EGFRCDK4CCND1CCND2CCND3
SCHEMBL30878368 0.82 CCNT1 (0.49) EGFRCDK4CCND1CCND2CCND3
SCHEMBL30879096 0.82 EGFR (0.45) EGFRCDK4CCND1CCND2CCND3
SCHEMBL30878376 0.78 CDK4 (0.52) EGFRCDK4CCND1CCND2CCND3
SCHEMBL30878415 0.78 CDK4 (0.68) EGFRCDK4CCND1CCND2CCND3
SCHEMBL30878529 0.77 CDK4 (0.55) EGFRCDK4CCND1CCND2CCND3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 EP claimed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 WO claimed
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 EP disclosed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 WO disclosed