Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 5/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 13/20 | 0.40 |
| ▸ | EGFR | P00533 | 7/20 | 0.40 |
| ▸ | SRC | P12931 | 7/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | WEE1 | P30291 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878989 | 0.89 | WEE1 (0.48) | RIPK2NOD2ACVR1FGFR1EGFR | |
| SCHEMBL30879101 | 0.84 | CYP1A2 (0.39) | ACVR1SRCWEE1ABL1 | |
| SCHEMBL30879082 | 0.82 | FGFR1 (0.40) | RIPK2ACVR1FGFR1EGFRSRC | |
| SCHEMBL30879095 | 0.77 | RIPK2 (0.37) | RIPK2NOD2ACVR1FGFR1EGFR | |
| SCHEMBL29498171 | 0.76 | FGFR1 (0.69) | RIPK2NOD2ACVR1FGFR1EGFR | |
| SCHEMBL3762584 | 0.76 | FGFR1 (0.69) | RIPK2NOD2ACVR1FGFR1EGFR | |
| SCHEMBL30878310 | 0.75 | EGFR (0.65) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL30879040 | 0.75 | KDM4E (0.39) | SRCABL1 | |
| SCHEMBL30878501 | 0.73 | FGFR1 (0.53) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL30878448 | 0.73 | ABL1 (0.68) | RIPK2NOD2ACVR1FGFR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |