SCHEMBL30878693

SCHEMBL30878693

CC(C)[Si](C#Cc1cc(=O)n(-c2ccccc2)c2nc(Nc3ccc(OCCN(C)C)cc3)ncc12)(C(C)C)C(C)C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 4/20 0.49
CCND1 P24385 4/20 0.49
CCND2 P30279 4/20 0.49
CCND3 P30281 4/20 0.49
SRC P12931 3/20 0.47
LCK P06239 2/20 0.47
KDR P35968 2/20 0.47
FGFR1 P11362 2/20 0.45
EGFR P00533 3/20 0.44
BTK Q06187 2/20 0.44
GAK O14976 1/20 0.44
ERBB2 P04626 1/20 0.44
JAK1 P23458 1/20 0.44
TTK P33981 1/20 0.44
TXK P42681 1/20 0.44
BLK P51451 1/20 0.44
JAK3 P52333 1/20 0.44
ITK Q08881 1/20 0.44
ERBB4 Q15303 1/20 0.44
RIPK2 O43353 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30878876 0.90 CDK4 (0.54) CDK4CCND1CCND2CCND3SRC
SCHEMBL30879096 0.88 EGFR (0.45) CDK4CCND1CCND2CCND3EGFR
SCHEMBL30878466 0.87 CDK4 (0.53) CDK4CCND1CCND2CCND3SRC
SCHEMBL30879043 0.87 EGFR (0.40) CDK4CCND1CCND2CCND3SRC
SCHEMBL30878942 0.84 EGFR (0.42) CDK4CCND1CCND2CCND3SRC
SCHEMBL30878988 0.80 CCND3 (0.51) CDK4CCND1CCND2CCND3SRC
SCHEMBL30879056 0.80 CDK4 (0.47) CDK4CCND1CCND2CCND3EGFR
SCHEMBL30878783 0.80 CDK4 (0.51) CDK4CCND1CCND2CCND3EGFR
SCHEMBL30878950 0.80 MAP4K1 (0.43) CDK4CCND1CCND2CCND3KDR
SCHEMBL30879189 0.80 CDK4 (0.52) CDK4CCND1CCND2CCND3FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 EP disclosed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 WO disclosed