Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isoleucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 12/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.35 |
| ▸ | FAP | Q12884 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoleucine SCHEMBL2496259 | 1.00 | DPP4 (0.37) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL2498263 | 1.00 | DPP4 (0.37) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL3099024 | 1.00 | DPP4 (0.37) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL6163458 | 1.00 | DPP4 (0.37) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL2493253 | 1.00 | DPP4 (0.37) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL2492485 | 1.00 | DPP4 (0.37) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL4400807 | 1.00 | DPP4 (0.37) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL4406285 | 1.00 | DPP4 (0.37) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL3062594 | 0.97 | DPP4 (0.36) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL27683514 | 0.97 | DPP4 (0.36) | DPP4DPP8DPP9DPP7FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006170-B2 | Compositions for elastogenesis and connective tissue treatment | HUMAN MATRIX SCIENCES, LLC (US) | 2015-04-14 | — | — | US | disclosed |
| US-7803522-B2 | Elastin producing fibroblast formulations and methods of using the same | HUMAN MATRIX SCIENCES, LLC (US) | 2010-09-28 | — | — | US | disclosed |
| US-20080050346-A1 | Elastin producing fibroblast formulations and methods of using the same | NULASTIN, INC. | 2008-02-28 | — | — | US | disclosed |