Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.53 |
| ▸ | ABL1 | P00519 | 10/20 | 0.53 |
| ▸ | ABL2 | P42684 | 9/20 | 0.53 |
| ▸ | SRC | P12931 | 13/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | TEK | Q02763 | 3/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | PRKDC | P78527 | 2/20 | 0.46 |
| ▸ | HCK | P08631 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20163047 | 1.00 | EGFR (0.53) | EGFRABL1ABL2SRCCDK1 | |
| SCHEMBL20162934 | 0.88 | PIK3CD (0.46) | EGFRABL1ABL2SRCKDR | |
| SCHEMBL20162764 | 0.85 | KDR (0.49) | EGFRABL1ABL2SRCKDR | |
| SCHEMBL30892144 | 0.85 | KDR (0.49) | EGFRABL1ABL2SRCKDR | |
| SCHEMBL20162939 | 0.82 | KDR (0.47) | EGFRABL1ABL2SRCCDK1 | |
| SCHEMBL30037546 | 0.82 | KDR (0.46) | EGFRABL1ABL2SRCKDR | |
| SCHEMBL20162651 | 0.82 | KDR (0.46) | EGFRABL1ABL2SRCKDR | |
| SCHEMBL20162649 | 0.82 | KDR (0.46) | EGFRABL1ABL2SRCKDR | |
| SCHEMBL30538106 | 0.82 | KDR (0.46) | EGFRABL1ABL2SRCKDR | |
| SCHEMBL20162640 | 0.73 | RET (0.46) | EGFRSRCKDRLCKTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4424311-A2 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation (US) | 2024-09-04 | — | — | EP | disclosed |
| EP-3541390-B1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUND (US) | 2024-05-01 | — | — | EP | disclosed |