Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 12/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 4/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27208127 | 0.89 | SRC (0.51) | CFTRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL20162689 | 0.87 | CFTR (0.64) | CFTRSRCLCKKDRTEK | |
| SCHEMBL30037538 | 0.87 | CFTR (0.64) | CFTRSRCLCKKDRTEK | |
| SCHEMBL20162724 | 0.85 | CFTR (0.45) | CFTRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30037442 | 0.85 | CFTR (0.45) | CFTRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL20162663 | 0.84 | KDR (0.48) | CFTRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30538071 | 0.84 | KDR (0.48) | CFTRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30036834 | 0.84 | KDR (0.48) | CFTRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL20168334 | 0.84 | KDR (0.48) | CFTRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL20162660 | 0.84 | KDR (0.48) | CFTRPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4424311-A2 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation (US) | 2024-09-04 | — | — | EP | disclosed |
| EP-3541390-B1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUND (US) | 2024-05-01 | — | — | EP | disclosed |