Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 11/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.40 |
| ▸ | TEK | Q02763 | 5/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30037196 | 1.00 | CFTR (0.47) | CFTRKDRTEKLCKSRC | |
| SCHEMBL20162744 | 1.00 | CFTR (0.47) | CFTRKDRTEKLCKSRC | |
| SCHEMBL20162743 | 1.00 | CFTR (0.47) | CFTRKDRTEKLCKSRC | |
| SCHEMBL20162918 | 0.92 | CFTR (0.46) | CFTRKDRTEKLCKSRC | |
| SCHEMBL30538092 | 0.90 | KDR (0.48) | CFTRKDRTEKLCKSRC | |
| SCHEMBL30038236 | 0.90 | KDR (0.48) | CFTRKDRTEKLCKSRC | |
| SCHEMBL20162623 | 0.90 | KDR (0.48) | CFTRKDRTEKLCKSRC | |
| SCHEMBL20162625 | 0.90 | KDR (0.48) | CFTRKDRTEKLCKSRC | |
| SCHEMBL30538094 | 0.84 | CFTR (0.41) | CFTRKDRTEKLCKSRC | |
| SCHEMBL20163013 | 0.84 | CFTR (0.41) | CFTRKDRTEKLCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4424311-A2 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation (US) | 2024-09-04 | — | — | EP | disclosed |
| EP-3541390-B1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUND (US) | 2024-05-01 | — | — | EP | disclosed |