Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 16/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162850 | 1.00 | CFTR (0.47) | CFTRRETRIPK2SRC | |
| SCHEMBL20162952 | 0.90 | CFTR (0.57) | CFTRRETSRC | |
| SCHEMBL20162741 | 0.84 | CFTR (0.47) | CFTR | |
| SCHEMBL20163056 | 0.83 | CFTR (0.51) | CFTR | |
| SCHEMBL30037476 | 0.83 | CFTR (0.51) | CFTR | |
| SCHEMBL20162991 | 0.83 | CFTR (0.38) | CFTR | |
| SCHEMBL20173278 | 0.83 | CFTR (0.38) | CFTR | |
| SCHEMBL20162993 | 0.83 | CFTR (0.38) | CFTR | |
| SCHEMBL20162721 | 0.80 | CFTR (0.53) | CFTRRETSRC | |
| SCHEMBL20162632 | 0.80 | CFTR (0.61) | CFTRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541390-B1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUND (US) | 2024-05-01 | — | — | EP | disclosed |