SCHEMBL30899433

SCHEMBL30899433

O=C1CC[C@H](NC(=O)c2c[nH]c3ccccc23)C(=O)N1

nearest known ligand 0.62

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 16/20 0.62
DDB1 Q16531 3/20 0.61
BRD4 O60885 2/20 0.54
CNR2 P34972 1/20 0.53
IKZF3 Q9UKT9 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20775426 1.00 CRBN (0.62) CRBNDDB1BRD4CNR2IKZF3
SCHEMBL20779009 1.00 CRBN (0.62) CRBNDDB1BRD4CNR2IKZF3
SCHEMBL20774154 1.00 CRBN (0.62) CRBNDDB1BRD4CNR2IKZF3
SCHEMBL30899453 1.00 CRBN (0.62) CRBNDDB1BRD4CNR2IKZF3
SCHEMBL30899452 1.00 CRBN (0.62) CRBNDDB1BRD4CNR2IKZF3
SCHEMBL30899429 1.00 CRBN (0.62) CRBNDDB1BRD4CNR2IKZF3
SCHEMBL22158624 0.83 CRBN (0.58) CRBNDDB1BRD4IKZF3
SCHEMBL22158625 0.83 CRBN (0.58) CRBNDDB1BRD4IKZF3
SCHEMBL24745153 0.82 CRBN (0.52) CRBNDDB1BRD4IKZF3
SCHEMBL20778965 0.80 CRBN (0.53) CRBNDDB1BRD4IKZF3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118108706-A Glutarimide C4医药公司 2024-05-31 CN disclosed
CN-111278815-B Glutarimide C4医药公司 2024-03-08 CN disclosed