Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.62 |
| ▸ | FLT3 | P36888 | 4/20 | 0.60 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.53 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.53 |
| ▸ | NEK6 | Q9HC98 | 2/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29226252 | 1.00 | PLK1 (0.62) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL30825072 | 0.87 | PLK1 (0.63) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226315 | 0.87 | PLK1 (0.63) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL30900315 | 0.87 | PLK1 (0.66) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226318 | 0.87 | PLK1 (0.66) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226302 | 0.82 | EGFR (0.58) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226213 | 0.80 | PLK1 (0.57) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL30900433 | 0.80 | PLK1 (0.57) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29227000 | 0.80 | PLK1 (0.58) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226256 | 0.79 | PLK1 (0.59) | PLK1FLT3PLK3PLK2NEK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117946098-A | Pyrimidine PLK1 inhibitor and preparation method and application thereof | 上海深势唯思科技有限责任公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-117658987-A | Compounds as PLK1 inhibitors, and preparation method and application thereof | 上海深势唯思科技有限责任公司 | 2024-03-08 | — | — | CN | disclosed |