Phosphine

Phosphine

SCHEMBL3090397

P.c1cnc2ncncc2n1

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 2/20 0.33
CHRNA3 P32297 2/20 0.33
CHRNA1 P02708 1/20 0.33
ESR1 P03372 1/20 0.33
CHRNG P07510 1/20 0.33
CHRNB1 P11230 1/20 0.33
CHRNB2 P17787 1/20 0.33
CHRNA5 P30532 1/20 0.33
CHRNA7 P36544 1/20 0.33
CHRNA4 P43681 1/20 0.33
HTR3A P46098 1/20 0.33
CHRND Q07001 1/20 0.33
CHRNA2 Q15822 1/20 0.33
EGFR P00533 1/20 0.33
PIK3CG P48736 1/20 0.33
METAP2 P50579 1/20 0.30
METAP1 P53582 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29355369 0.97 EGFR (0.34) CHRNB4CHRNA3CHRNA1ESR1CHRNG
SCHEMBL7626 0.97 EGFR (0.34) CHRNB4CHRNA3CHRNA1ESR1CHRNG
SCHEMBL28134927 0.95 EGFR (0.33) EGFRPIK3CGMETAP2METAP1
Hydrochloric Acid SCHEMBL27567069 0.95 EGFR (0.33) CHRNB4CHRNA3EGFRPIK3CGMETAP2
Bromide SCHEMBL9315292 0.95 EGFR (0.33) EGFRPIK3CGMETAP2METAP1
SCHEMBL27705809 0.95 EGFR (0.33) EGFRPIK3CGMETAP2METAP1
Potassium SCHEMBL29619940 0.95 EGFR (0.33) EGFRPIK3CGMETAP2METAP1
Hydrogen Sulfide SCHEMBL29184284 0.95 EGFR (0.33) EGFRPIK3CGMETAP2METAP1
Ammonia Solution, Strong SCHEMBL27506828 0.95 EGFR (0.33) EGFRPIK3CGMETAP2METAP1
Benzene SCHEMBL28734212 0.93 EGFR (0.37) EGFRPIK3CGMETAP2METAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100227798-A1 USE OF THE STAUDINGER LIGATION IN IN VIVO ASSEMBLY OF A BIOLOGICALLY ACTIVE COMPOUND KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) 2010-09-09 US disclosed
CN-101410139-A Use of the staudinger ligation in in vivo assembly of a biologically active compound KONINKL PHILIPS ELECTRONICS NV (NL) 2009-04-15 CN disclosed
EP-2001512-A2 USE OF THE STAUDINGER LIGATION IN IN VIVO ASSEMBLY OF A BIOLOGICALLY ACTIVE COMPOUND Koninklijke Philips Electronics N.V. (NL) 2008-12-17 EP disclosed
WO-2007110811-A2 USE OF THE STAUDINGER LIGATION IN IN VIVO ASSEMBLY OF A BIOLOGICALLY ACTIVE COMPOUND KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) 2007-10-04 WO disclosed