SCHEMBL30904698

SCHEMBL30904698

Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCC(N5CCOCC5)CC4)ncc3Cl)ccc21

nearest known ligand 0.86

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 20/20 0.86
▸ NCOR2 Q9Y618 7/20 0.86
▸ ADRB3 P13945 1/20 0.68
▸ HTR1D P28221 1/20 0.68
▸ ADORA1 P30542 1/20 0.68
▸ OPRM1 P35372 1/20 0.68
▸ SLC6A3 Q01959 1/20 0.68
▸ TMEM97 Q5BJF2 1/20 0.68
▸ HRH3 Q9Y5N1 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20569199 1.00 BCL6 (0.86) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL23357499 0.93 BCL6 (1.00) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL29960105 0.93 BCL6 (1.00) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL31211517 0.90 BCL6 (0.83) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL23357507 0.90 BCL6 (0.83) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL23267548 0.89 BCL6 (0.84) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL23267142 0.88 BCL6 (0.83) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL23267500 0.87 BCL6 (0.82) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL20569646 0.87 BCL6 (0.74) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL30904707 0.87 BCL6 (0.74) BCL6NCOR2ADRB3HTR1DADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111163839-B Benzimidazolone-derived BCL6 inhibitors 癌症研究科技有限公司 2024-05-28 — — CN claimed
US-20240417388-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-12-19 — — US disclosed
US-12110286-B2 Benzimidazolone derived inhibitors of BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-10-08 — — US disclosed
CN-118561812-A Benzimidazolone-derived BCL6 inhibitors 癌症研究科技有限公司 2024-08-30 — — CN disclosed
CN-111163839-B Benzimidazolone-derived BCL6 inhibitors 癌症研究科技有限公司 2024-05-28 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240417388-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 BCL6, BCL6B, BCL3 BCL6 1/4885NCOR2 341/4885ADRB3 3749/4885
US-12110286-B2 Benzimidazolone derived inhibitors of BCL6 BCL6, BCL6B, BCL3 BCL6 1/4885NCOR2 341/4885ADRB3 3749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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