SCHEMBL30907141

SCHEMBL30907141

CCC(=O)c1cc(C)c(-c2cc3cnc(NC(=O)[C@H]4C[C@H]4F)cc3cn2)cn1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 17/20 0.68
MAP4K1 Q92918 3/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30907191 1.00 ABL1 (0.68) ABL1MAP4K1
SCHEMBL30907271 0.92 ABL1 (0.66) ABL1MAP4K1
SCHEMBL30907122 0.92 ABL1 (0.66) ABL1MAP4K1
SCHEMBL30907096 0.90 ABL1 (0.65) ABL1MAP4K1
SCHEMBL30907446 0.90 ABL1 (0.65) ABL1MAP4K1
SCHEMBL15608828 0.89 ABL1 (0.72) ABL1MAP4K1
SCHEMBL30907339 0.89 ABL1 (0.65) ABL1MAP4K1
SCHEMBL14245087 0.87 ABL1 (0.69) ABL1MAP4K1
SCHEMBL30907251 0.86 ABL1 (0.52) ABL1MAP4K1
SCHEMBL30907604 0.86 ABL1 (0.61) ABL1MAP4K1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024097953-A1 NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES ENLIVEN INC. (US) 2024-05-10 WO disclosed