Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 18/20 | 0.46 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30907158 | 1.00 | ABL1 (0.46) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL30907109 | 1.00 | ABL1 (0.46) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL30907118 | 0.91 | ABL1 (0.53) | ABL1NNMT | |
| SCHEMBL30907244 | 0.91 | ABL1 (0.53) | ABL1NNMT | |
| SCHEMBL30907550 | 0.91 | ABL1 (0.53) | ABL1NNMT | |
| SCHEMBL30907488 | 0.88 | ABL1 (0.50) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL30907617 | 0.88 | ABL1 (0.50) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL30907499 | 0.88 | ABL1 (0.50) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL30907292 | 0.87 | ABL1 (0.52) | ABL1 | |
| SCHEMBL30907633 | 0.87 | ABL1 (0.45) | ABL1KRASRAF1BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024097953-A1 | NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES | ENLIVEN INC. (US) | 2024-05-10 | — | — | WO | disclosed |