Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.74 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.74 |
| ▸ | STK10 | O94804 | 2/20 | 0.74 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.74 |
| ▸ | RET | P07949 | 2/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.74 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.74 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.74 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.74 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.74 |
| ▸ | ABL1 | P00519 | 1/20 | 0.74 |
| ▸ | EGFR | P00533 | 1/20 | 0.74 |
| ▸ | LCK | P06239 | 1/20 | 0.74 |
| ▸ | CSF1R | P07333 | 1/20 | 0.74 |
| ▸ | HCK | P08631 | 1/20 | 0.74 |
| ▸ | KIT | P10721 | 1/20 | 0.74 |
| ▸ | SRC | P12931 | 1/20 | 0.74 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2263514 | 1.00 | KDR (0.74) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL20538934 | 1.00 | KDR (0.74) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL18825560 | 1.00 | KDR (0.74) | KDRCYP3A4FGFR1KCNH2STK10 | |
| Alanine SCHEMBL2729838 | 0.97 | CYP3A4 (0.73) | KDRCYP3A4FGFR1KCNH2STK10 | |
| Brivanib SCHEMBL29354510 | 0.85 | KDR (1.00) | KDRCYP3A4FGFR1KCNH2STK10 | |
| Brivanib SCHEMBL1227111 | 0.85 | KDR (1.00) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL1227534 | 0.85 | KDR (0.83) | KDRCYP3A4FGFR1KCNH2STK10 | |
| Brivanib SCHEMBL1227589 | 0.85 | KDR (1.00) | KDRCYP3A4FGFR1KCNH2STK10 | |
| Brivanib SCHEMBL1227112 | 0.85 | KDR (1.00) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL17377930 | 0.85 | CYP3A4 (0.76) | KDRCYP3A4FGFR1KCNH2STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112261970-B | 3- (5-Hydroxy-1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and their use in the treatment of IKAROS family zinc finger 2 (IKZF 2) dependent diseases | 诺华股份有限公司 | 2025-02-07 | — | — | CN | disclosed |
| CN-116134027-B | Heteroaryl-substituted 3- (1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof | 诺华股份有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-119241499-A | 3- (5-Hydroxy-1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof | 诺华股份有限公司 | 2025-01-03 | — | — | CN | disclosed |
| CN-112334194-B | 3- (5-Amino-1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and their use in the treatment of I KAROS family zinc finger 2 (IKZF 2) dependent diseases | 诺华股份有限公司 | 2024-12-06 | — | — | CN | disclosed |
| CN-113490528-B | 3- (1-Oxo-5- (piperidin-4-yl) isoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof | 诺华股份有限公司 | 2024-12-03 | — | — | CN | disclosed |
| CN-113329792-B | Substituted 3- (1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof | 诺华股份有限公司 | 2024-06-28 | — | — | CN | disclosed |